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বুধবার, ৭ নভেম্বর, ২০১২

Trivial Pursuit Card Game Only $5 Shipped!

by Alli on November 6, 2012

Amazon has the Trivial Pursuit Card Game on sale right now for only $.01 with $4.99 in shipping. That?s only $5 shipped! Pick up a few of these as gifts for the holidays or stash some away in the toy closet! The price is right!

When you?re done here, be sure to visit my Amazon section for all the best?Amazon deals!

Prices at Amazon can flip fast, so don?t wait too long if you?re interested! And don?t forget to use your Amazon gift certificates from?Swagbucks?to get an even better deal!

Trivial Pursuit Digital Choice Game Only $9.99!
Game Party 2 Wii Game Only $8.66 Shipped!
EA Sports Active 2 Game Only $39.99 Shipped!
Scrabble Slam Card Game Only $3.50!
Hasbro Family Game Night Bundle For Wii Only $39.95 Shipped!

Source: http://www.couponingfor4.net/2012/11/trivial-pursuit-card-game-only-5-shipped/

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The stunning collection of weather photographs showing the ...

This incredible set of photographs shows nature at its wildest and most beautiful.

The Bureau of Meteorology and Australian Meteorological and Oceanographic Society organises a competition each year for the best weather pictures.

And its 2013 calendar is one of its best yet with lightning bolts, dust storms and enormous clouds creating dramatic series of natural spectacles.

Majesty and threat ? a majestic cumulonimbus with anvil seen beyond wind turbines at Burra, South Africa, by photographer Helen Simpson for The April photorgaph in the Australian Bureau of Meteorology calender 2013

The ethereal beauty of a mist bow and fog at Mount Anne in Tasmania by Grant Dixon for August

The February shows a thunderstorm sweeping over the Melbourne suburb of Carrum Downs by Flavio Bonicelli

One of the star moments Down Under was captured by amateur photographer James Collier after he witnessed a thunderstorm in March.

James, from Geelong, Victoria, watched as the storm cell caused an abrupt increase in wind ? with gusts jumping from 30 km/h to 115 km/h as the storm passed nearby.

He said: ?It was calm, almost surreal. I was clicking off ten second time exposures when all of a sudden it let go.

?I really jumped and nearly fell out the back of the wagon. I wasn?t sure I had pressed the button and had several seconds of anxiety before I confirmed that I had it.

Lightning illuminates a cumulonimbus cloud over Corio Bay, Victoria by James Collier

Nature complements fireworks during Australia Day 2012 celebrations in Perth, in a stunning shot by Matthew Titmanis

A squall line associated with a thunderstorm over Era Beach, south of Sydney by photographer Bruce Cooper for July

?There was a lot of sheet lightning and only the occasional bolt, missing what I thought was the best bolt as I adjusted the camera.

?I continued to shoot when the cell let go with this massive bolt. It was stunning to watch but all over in a second. I very nearly didn?t go out that night.?

Matt Titmanis shot nature and man made in perfect harmony for January.

The science teacher, from Perth, was on his way to Australia Day celebrations in January this year when he got his camera out.

Sunset highlights streets of stratocumulus over Buninyong, central Victoria by Keith Day

Ship in sea fog off McCrae, Port Phillip Bay, Victoria, by photographer Meredith Banhidi for May

In the wake of a thunderstorm, hail blankets paddocks at Marong, Victoria by John Allen

With perfect timing, Matt photographed a multi-coloured fireworks display in the foreground of a huge lightning storm.

And full-time photographer Peter Macdonald, who has specialised in shooting the outback for 20-years, was left mesmerised by the dust storm used in September.

The photo, taken in 2008, captures the sheer size of the 50km storm which was so large it only within the lens from 4km away.

Peter, from South Australia, said: ?Unfortunately I left it too late to run. A howling mass of sand hit me, I could barely see, and had difficulty finding the car.

?When I did I stupidly opened the door and it was amazing how much sand got in.

The November shadows of cumulus clouds dapple the parallel dunes of the Simpson Desert by Steve Strike

A thunderstorm threatens the Gold Coast, Queensland by
photographer Ann Van Breemen for October

A massive dust storm rolls over the Arkaroola Wilderness Sanctuary in the northern Flinders Ranges of South Australia, in this stunning photograph by Peter MacDonald

?It was around 45 minutes before the storm turned into something like a sandy fog with visibility increased to 100 metres.?

The calendar, now in its 29th year, was launched to promote the understanding of meteorology and oceanography.

This year saw hundreds of entrees, leaving project manager Robert Kershaw with the daunting task of whittling it down to 13 for the calendar and front cover.

Robert said: ?From an Australia Day lightning display that competes with fireworks in Perth, to rows of deep pink and violet stratocumulous clouds in country Victoria, or clouds casting dappled shadows on the terracotta-coloured Simpson Desert ? this calendar presents an enduring record of the moments when nature puts on her most dramatic show.?

The calendar can be purchased from: http://shop.bom.gov.au.

Category: Pictures

Source: http://swns.com/news/mother-nature-awesome-stunning-collection-weather-photographs-showing-elements-full-force-27177/

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শনিবার, ৩ নভেম্বর, ২০১২

Sandy death toll in US rises to 109; 'there could be more ...

The National Guard, FEMA and the Red Cross, among other agencies, set up camp to help the hard-hit working class community of Staten Island. NBC's Andrea Canning reports.

By Miguel Llanos, NBC News

Updated 11:20 p.m. ET: The death toll in the United States from Superstorm Sandy rose to 109 victims on Friday, as Pennsylvania reported four additional deaths and New York City reported two more fatalities. Mayor Michael Bloomberg warned: "There could be more fatalities."

Two bodies were recovered Friday on Staten Island. The toll in the nation's largest city is now 41 deaths, according to the governor's office. However, the New York Police Department had reported 40 deaths in the city.

Half of the city's deaths were on Staten Island and Bloomberg noted the deaths there of two brothers swept from their mother's arms in the storm surge.?

"It just breaks your heart to think about it," Bloomberg said.

Besides New York City, the deaths NBC News has confirmed are:

New Jersey: 22
Pennsylvania: 12
Maryland: 11
Rest of New York state: 8
West Virginia: 6
Connecticut: 4
Virginia: 2
North Carolina: 2
Puerto Rico: 1

The storm also killed at least 69 people in the Caribbean, including 54 in Haiti and 11 in Cuba.?

Tempers flared as people camped out all night, waiting for their turn at the pump in the wake of Superstorm Sandy. NBC's Tom Costello reports.

Four days after Sandy struck the U.S., New York and the wider region were in full recovery mode Friday:

NYC Marathon:?Bloomberg said it was being canceled?even though he had earlier defended the decision to hold it Sunday.
Gasoline shortages:?New York Harbor reopened Friday, providing a critical refueling supply line for the region. But motorists still waited in long lines for gasoline.
Manhattan traffic:?New York City said it had lifted, as of 5 p.m. ET, the order that vehicles entering Manhattan must have at least three occupants.
Shelter, food aid: 5,500 people are still in 15 New York City shelters and some could be out of their homes long term.?The city on Thursday gave out 290,000 meals and 500,000 bottles of water at 13 stations. Those deliveries will continue indefinitely. But residents of outlying areas like Staten Island and Coney Island complained aid was little and late. "People are defecating in the hallways," one Coney Island resident without power or water?told NBC 4 New York.
Damage cost: In New York state alone, the cost could exceed $18 billion, a state official said Friday. Private estimates for the entire region range up to $50 billion in economic losses.
N.J. beach homes: Thousands of people were still not allowed to return to their Jersey coast properties due to safety concerns. Gov. Chris Christie said Friday he had his first meeting with the Army Corps of Engineers to work on how and where to rebuild along the shore.
Casinos reopen: Atlantic City, N.J., was given the green light to reopen casinos on Friday.
Military help:?Nearly 7,400 National Guard members have provided support, giving out 144,000 meals in New York City and Long Island, rescuing more than 2,000 people and 200 pets, and clearing debris, the Department of Defense said. Equipment and supplies are being delivered, including: ships to New York City to give first responders a place to rest; millions of meals from West Virginia to New York; and trucks that will deliver about 200,000 gallons of fuel.

New Yorkers also got a bit of a scare Friday when police ammo and explosives ruined during the storm were detonated in several controlled explosions on Ellis Island.

Superstorm Sandy made landfall Monday evening on a destructive and deadly path across the Northeast.

More content from NBCNews.com:

Source: http://usnews.nbcnews.com/_news/2012/11/02/14884300-sandy-death-toll-in-us-rises-to-109-there-could-be-more-bloomberg-warns

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AP source: NHL cancels Winter Classic at Big House

ANN ARBOR, Mich. (AP) ? The NHL has canceled the 2013 Winter Classic at Michigan Stadium.

The signature event between the Detroit Red Wings and Toronto Maple Leafs, is the latest casualty from the labor dispute that has put the season on hold, a person familiar with the situation told The Associated Press on Friday. The person, who spoke on condition of anonymity because the league had not yet announced the move, also said the NHL will schedule its next Winter Classic at the iconic stadium that seats more than 100,000 people.

There have been no labor negotiations since Oct. 18, when the players' union countered a league offer with three proposals. Those were all quickly rejected by the NHL. Since then, a league-imposed deadline to play a full season has passed, and the NHL cancelled all games through Nov. 30.

Detroit and Toronto, two of the league's Original Six teams, were scheduled to play outdoors on Jan. 1 at the stadium known as the Big House and the league was hoping the matchup would break the world record for hockey attendance. Michigan and Michigan State's hockey teams drew a record 104,173 fans in 2010.

Buffalo, Chicago, Boston, Pittsburgh and Philadelphia have all hosted the Winter Classic, but the crowd for a game at Michigan Stadium was expected to draw the league's largest crowd. The last Classic at Philadelphia's Citizens Bank Park drew 46,967, and the New York Rangers beat the host Flyers 3-2.

___

Follow Larry Lage on Twitter: http://twitter.com/larrylage

Source: http://news.yahoo.com/ap-source-nhl-cancels-winter-classic-big-house-165620880--nhl.html

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New medication shows promise as lipid-lowering therapy for rare cholesterol disorder

ScienceDaily (Nov. 1, 2012) ? An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

Penn researchers report in The Lancet that lomitapide, a first-in-class microsomal triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH). Lomitapide works by inhibiting MTP, which is required for the production of VLDL -- the precursor to LDL.

HoFH patients have markedly elevated blood levels of cholesterol -- generally greater than 500 mg/dL -- due to genetic mutations in the LDL receptor gene that result in impaired ability of the liver to remove LDL from the blood. Heart and vascular disease often develop in childhood, and the average age of death even with current therapies is about 30 years. HoFH patients do not respond well to the usual treatments for elevated cholesterol, such as statins. The only effective therapy for these patients is apheresis, an invasive and time-consuming procedure that involves physically removing excess LDL from the bloodstream and must be repeated every one to two weeks.

The current study was an open-label trial that comprised a six-month phase designed to assess the efficacy of lomitapide when added to standard of care and an additional year-long phase to assess safety and tolerability. Twenty-nine adult HoFH patients from across the world were enrolled, with 23 patients completing both the efficacy and the safety phases. All of the patients received lomitapide along with conventional lipid-lowering therapies including statins and, in some cases, apheresis. The lomitapide dose was gradually increased from 5 mg to a maximum tolerated dose of up to 60 mg per day. Median dose was 40 mg per day. At the end of the efficacy phase, LDL-C levels were reduced by an average of 50 percent from baseline. Approximately one-third of the patients experienced levels of LDL-C that were less than 100 mg/dl -- close to the recommended therapeutic goals -- at some point during the study, and concomitant lipid-lowering therapy was modified in a subset of these patients during the safety phase. Despite these changes in treatment, patients' mean LDL-C levels were still reduced by 38 percent at the end of the study.

"The magnitude of this reduction in LDL-C and the fact that some patients reached or approached the LDL-C therapeutic goals is truly remarkable for this high risk population that historically doesn't respond to lipid-lowering drugs," said the study's lead author, Marina Cuchel, MD, PhD, research assistant professor of Medicine at Penn. "A reduction in LDL-C of this magnitude is certainly expected to favorably alter the clinical course of this devastating disease."

Senior study author Daniel J. Rader, MD, chief, Division of Translational Medicine and Human Genetics, has treated HoFH patients for more than two decades. In the early 1990s, Rader worked with colleagues to determine that mutations in MTP were the cause of a rare condition characterized by absent LDL in the blood, establishing MTP as a therapeutic target to reduce LDL. His colleagues then went on to discover the MTP inhibitor lomitapide at Bristol-Myers Squibb (BMS). Rader led a study at Penn in the late 1990s showing that lomitapide substantially reduced LDL in patients with moderately elevated LDL. However, because the agent caused some gastrointestinal side effects and increased liver fat, BMS decided to abandon further development of lomitapide for a much larger population of patients with elevated levels of cholesterol. Rader convinced BMS to donate the drug to Penn so that he could continue to develop it in patients with HoFH. Based on its mechanism and on a study in a rabbit model of the disease, Rader felt it would be effective against HoFH.

A proof of principle study conducted by Drs. Cuchel and Rader at Penn in six HoFH patients confirmed that lomitapide was highly effective in reducing LDL and provided the basis for the international phase 3 study, which was funded in part by the Office of Orphan Product Development at the Food and Drug Administration (FDA). Aegerion Pharmaceuticals in-licensed lomitapide from Penn in 2006, helping fund the completion of the study and the additional work required to submit a new drug application to the FDA.

On October 17, 2012, the FDA's Endocrinologic and Metabolic Drugs Advisory Committee recommended by a vote of 13 to 2 the approval of lomitapide to reduce LDL in patients with HoFH. The FDA is scheduled to make a final decision on approval of the medication by the end of year.

"The more than 15-year story of this therapy is the result of an enormous collaboration between academia, foundation, pharmaceutical and biotech industries, and the government," said Rader. "If lomitapide is approved and is made available to patients with this fatal disease, it will serve as a model for how different sectors can work together to bring new medicines to patients with large unmet medical need."

Other study authors from Penn include Emma A. Meagher, MD, and Kathleen J. Propert, ScD. The site study team at Penn included also Daniel Kolansky, MD and Bruce Sachais, MD, PhD.

The study was supported by grants from the FDA Office of Orphan Product Development (FR-R-003098), the National Center for Research Resources (UL1-RR-024134), and by Aegerion Pharmaceuticals.

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Story Source:

The above story is reprinted from materials provided by University of Pennsylvania School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Marina Cuchel, Emma A Meagher, Hendrik du Toit Theron, Dirk J Blom, A David Marais, Robert A Hegele, Maurizio R Averna, Cesare R Sirtori, Prediman K Shah, Daniel Gaudet, Claudia Stefanutti, Giovanni B Vigna, Anna ME Du Plessis, Kathleen J Propert, William J Sasiela, LeAnne T Bloedon, Daniel J Rader. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. The Lancet, 2012; DOI: 10.1016/S0140-6736(12)61731-0

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/fi1399b9vfA/121102115440.htm

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New radio ad from Dem. Senate hopeful Warren tweaks GOP Sen. Brown for refusing debate offer (Star Tribune)

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Lennon's Tooth to Help Fight Cancer

Imagine there's no oral cancer. It isn't hard to do. You may say I'm a dreamer. But I'm not the only one.

Those rewritten John Lennon lyrics may be Tony Gedge's new motto.

Gedge has made it his life's work to reduce the rates of oral cancer in his native Britain. And now, Gedge has enlisted the former Beatle to help inspire Brits to walk into the dentist and receive a simple, 10-minute-long test for oral cancer.

Specifically, Gedge has turned to one of John Lennon's molars.

Encased in a smart silver pendant, Lennon's tooth is going on tour. Walk into your dentist's office, try on the necklace with the tooth, and get a free cancer screening.

"The biggest group at risk for oral cancer are males, 55-59," Gedge told ABC News. "They were around when the Beatles were doing their thing. So to appeal to the 55-plus boomer market, to get them into the practice with something they know ? the Beatles ? was far easier than getting them in by spouting a bunch of statistics."

In 2010 in Britain, nearly 2,000 people died from oral cancer. In the U.S., that number was 7,850, with more than 40,000 new cases. If the cancer is caught early, most people will survive. (Click here for the National Cancer Institute's guide to preventing Oral Cancer.)

For Gedge, those statistics are personal.

Gedge lost his father to mouth cancer, and his mother now feeds through a tube because she too had oral cancer.

"Since that happened, I've been working with dentists to help them promote dentistry to make it more interesting to the general public," he says.

In the mid 1960s, Lennon gave his tooth to his housekeeper, Dot Jarlett, while she worked at his home southwest of London. Her family kept it until last year, when Canadian dentist Michael Zuk bought it in an auction for more than $31,000.

Zuk then created three necklaces containing fragments of tooth and sent one to Gedge, who runs a charity called Dental Mavericks.

In the next few weeks the necklace will visit 16 dental practices. Dentists will check anyone who comes in to see the tooth for oral cancer ? an easy and painless detection that can be done with the help of a special light.

Castlepark Dental Centre in Hull in northeast England, one of the first practices taking part, has already screened about 100 people, Gillian Fisher, the practice manager, told ABC News.

"Fifty years ago this week the Beatles were playing at the local cinema," Fisher said. "The patients were coming in and talking about what they were wearing, what they were playing. It was a total trip down memory lane for them. Through the curiosity we're hoping to raise awareness of mouth cancer."